LAG3
Gene Information
- Official Symbol: LAG3
- Official Name: lymphocyte activating 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 3902
- UniProt: P18627
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in lymphocyte activation. Binds to HLA class-II antigens.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| plasmacytoid dendritic cell activation |
| negative regulation of interleukin-2 biosynthetic process |
| negative regulation of regulatory T cell differentiation |
| MHC class II protein binding |
| regulation of interleukin-2 biosynthetic process |
| negative regulation of interleukin-2 production |
| positive regulation of natural killer cell mediated cytotoxicity |
| regulation of regulatory T cell differentiation |
| negative regulation of cytokine biosynthetic process |
| positive regulation of natural killer cell mediated immunity |
| negative regulation of T cell differentiation |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| negative regulation of lymphocyte differentiation |
| regulation of interleukin-2 production |
| positive regulation of leukocyte mediated cytotoxicity |
| positive regulation of cell killing |
| regulation of leukocyte mediated cytotoxicity |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| negative regulation of leukocyte differentiation |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| regulation of cell killing |
| positive regulation of lymphocyte mediated immunity |
| regulation of cytokine biosynthetic process |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of leukocyte mediated immunity |
| negative regulation of hemopoiesis |
| transmembrane signaling receptor activity |
| regulation of T cell differentiation |
| antigen binding |
| negative regulation of lymphocyte activation |
| regulation of lymphocyte mediated immunity |
| regulation of lymphocyte differentiation |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| negative regulation of cell activation |
| regulation of leukocyte mediated immunity |
| antigen processing and presentation |
| positive regulation of immune effector process |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| adaptive immune response |
| regulation of cell activation |
| regulation of cell adhesion |
| regulation of cytokine production |
| negative regulation of cell differentiation |
| regulation of defense response |
| regulation of multi-organism process |
| positive regulation of immune response |
| leukocyte activation |
| negative regulation of developmental process |
| cell activation |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of immune system process |
| regulation of cell differentiation |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.001μM R01 exp41 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2990
- Expression level (log2 read counts): -4.01
Expression Distribution
LAG3 Expression in NALM6 Cells: -4.01
