LAMB3
Gene Information
- Official Symbol: LAMB3
- Official Name: laminin subunit beta 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 3914
- UniProt: Q13751
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8621
- Expression level (log2 read counts): -3.13
LAMB3 Expression in NALM6 Cells: -3.13
