LAMP3
Gene Information
- Official Symbol: LAMP3
- Official Name: lysosomal associated membrane protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 27074
- UniProt: Q9UQV4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in dendritic cell function and in adaptive immunity. {ECO:0000269|PubMed:9768752}.
Pfam Domains GO Terms
Pfam Domains
| Lamp |
GO Terms
| alveolar lamellar body membrane |
| response to interferon-alpha |
| negative regulation of proteasomal protein catabolic process |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cellular protein catabolic process |
| negative regulation of cysteine-type endopeptidase activity |
| viral entry into host cell |
| entry into host |
| entry into host cell |
| late endosome membrane |
| negative regulation of protein catabolic process |
| vesicle |
| regulation of viral life cycle |
| interaction with host |
| regulation of proteasomal protein catabolic process |
| viral life cycle |
| regulation of viral process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| regulation of cellular protein catabolic process |
| negative regulation of cellular catabolic process |
| negative regulation of peptidase activity |
| early endosome |
| lysosomal membrane |
| negative regulation of catabolic process |
| regulation of autophagy |
| negative regulation of proteolysis |
| regulation of protein catabolic process |
| regulation of endopeptidase activity |
| establishment of protein localization to organelle |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| adaptive immune response |
| intracellular membrane-bounded organelle |
| perinuclear region of cytoplasm |
| viral process |
| regulation of proteolysis |
| protein localization to organelle |
| regulation of multi-organism process |
| symbiotic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| regulation of catabolic process |
| negative regulation of cellular protein metabolic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of hydrolase activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell death |
| immune response |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5867
- Expression level (log2 read counts): 1.33
Expression Distribution
LAMP3 Expression in NALM6 Cells: 1.33
