LAT2
Gene Information
- Official Symbol: LAT2
- Official Name: linker for activation of T cells family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7462
- UniProt: Q9GZY6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008].
- UniProt Summary: Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. {ECO:0000269|PubMed:12486104, ECO:0000269|PubMed:12514734, ECO:0000269|PubMed:15010370}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7635
- Expression level (log2 read counts): 7.85
LAT2 Expression in NALM6 Cells: 7.85
