LCN2
Gene Information
- Official Symbol: LCN2
- Official Name: lipocalin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3934
- UniProt: P80188
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Lipocalin |
GO Terms
| enterobactin binding |
| siderophore transport |
| sequestering of iron ion |
| response to mycotoxin |
| iron coordination entity transport |
| sequestering of metal ion |
| response to herbicide |
| small molecule binding |
| signal transduction in absence of ligand |
| extrinsic apoptotic signaling pathway in absence of ligand |
| protein homotrimerization |
| protein trimerization |
| cellular iron ion homeostasis |
| specific granule lumen |
| cellular response to hydrogen peroxide |
| iron ion transport |
| iron ion homeostasis |
| extrinsic apoptotic signaling pathway |
| positive regulation of cold-induced thermogenesis |
| protease binding |
| cellular transition metal ion homeostasis |
| antimicrobial humoral response |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| transition metal ion transport |
| transition metal ion homeostasis |
| cellular response to reactive oxygen species |
| iron ion binding |
| regulation of cold-induced thermogenesis |
| maintenance of location |
| cellular response to interleukin-1 |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| response to reactive oxygen species |
| response to interleukin-1 |
| cellular response to toxic substance |
| cellular response to biotic stimulus |
| cellular response to nutrient levels |
| cellular response to oxidative stress |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| cellular response to extracellular stimulus |
| response to virus |
| apoptotic signaling pathway |
| response to antibiotic |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| defense response to bacterium |
| cellular response to external stimulus |
| protein homooligomerization |
| humoral immune response |
| positive regulation of cell projection organization |
| response to oxidative stress |
| cellular response to drug |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| response to nutrient levels |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| response to toxic substance |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| cellular response to lipid |
| myeloid cell activation involved in immune response |
| response to extracellular stimulus |
| response to inorganic substance |
| cellular metal ion homeostasis |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| metal ion homeostasis |
| cell activation involved in immune response |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulated exocytosis |
| cation homeostasis |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| innate immune response |
| leukocyte mediated immunity |
| ion homeostasis |
| exocytosis |
| cation transport |
| response to lipid |
| protein homodimerization activity |
| cellular homeostasis |
| apoptotic process |
| leukocyte activation |
| defense response to other organism |
| secretion by cell |
| cellular response to cytokine stimulus |
| response to drug |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell activation |
| cell death |
| immune effector process |
| response to cytokine |
| chemical homeostasis |
| secretion |
| positive regulation of cellular component organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| extracellular space |
| homeostatic process |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.001μM R01 exp41 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6472
- Expression level (log2 read counts): -7.68
Expression Distribution
LCN2 Expression in NALM6 Cells: -7.68
