LCP2
Gene Information
- Official Symbol: LCP2
- Official Name: lymphocyte cytosolic protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3937
- UniProt: Q13094
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in T-cell antigen receptor mediated signaling.
Pfam Domains GO Terms
Pfam Domains
| SH2 |
| SAM 2 |
GO Terms
| TCR signalosome |
| mast cell activation |
| plasma membrane raft |
| cytokine secretion |
| platelet activation |
| cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| cell-cell junction |
| peptide secretion |
| Fc-epsilon receptor signaling pathway |
| T cell receptor signaling pathway |
| Fc receptor signaling pathway |
| blood coagulation |
| antigen receptor-mediated signaling pathway |
| coagulation |
| hemostasis |
| immune response-activating cell surface receptor signaling pathway |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of body fluid levels |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| positive regulation of protein kinase activity |
| immune response-activating signal transduction |
| response to wounding |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| activation of immune response |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of protein kinase activity |
| positive regulation of immune response |
| regulation of kinase activity |
| leukocyte activation |
| regulation of transferase activity |
| secretion by cell |
| positive regulation of protein phosphorylation |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of protein modification process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| protein transport |
| peptide transport |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| nitrogen compound transport |
| regulation of protein modification process |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vinblastine 0.2μM R03 exp108 | -1.7 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.625 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6722
- Expression level (log2 read counts): 1.52
Expression Distribution
LCP2 Expression in NALM6 Cells: 1.52
