LDB2
Gene Information
- Official Symbol: LDB2
- Official Name: LIM domain binding 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9079
- UniProt: O43679
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
Pfam Domains GO Terms
Pfam Domains
| LIM bind |
GO Terms
| LIM domain binding |
| epithelial structure maintenance |
| cell leading edge |
| RNA polymerase II activating transcription factor binding |
| somatic stem cell population maintenance |
| hair follicle development |
| skin epidermis development |
| hair cycle process |
| molting cycle process |
| transcription coregulator activity |
| hair cycle |
| molting cycle |
| stem cell population maintenance |
| maintenance of cell number |
| tissue homeostasis |
| transcription factor complex |
| multicellular organismal homeostasis |
| anatomical structure homeostasis |
| enzyme binding |
| skin development |
| epidermis development |
| positive regulation of cellular component biogenesis |
| regulation of cell migration |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Adefovir 20μM R07 exp332 | 1.77 |
| 2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 | 1.99 |
| DABN 20μM R00 exp17 | 2.24 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15076
- Expression level (log2 read counts): -0.82
Expression Distribution
LDB2 Expression in NALM6 Cells: -0.82
