LEFTY1
Gene Information
- Official Symbol: LEFTY1
- Official Name: left-right determination factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10637
- UniProt: O75610
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| transforming growth factor beta receptor binding |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| SMAD protein signal transduction |
| regulation of pathway-restricted SMAD protein phosphorylation |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| specification of symmetry |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| growth factor activity |
| cytokine activity |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| heart morphogenesis |
| pattern specification process |
| cellular response to growth factor stimulus |
| heart development |
| response to growth factor |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| animal organ morphogenesis |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.421 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13713
- Expression level (log2 read counts): -5.6
Expression Distribution
LEFTY1 Expression in NALM6 Cells: -5.6
