LEFTY2

• Official Symbol: LEFTY2
• Official Name: left-right determination factor 2
• Aliases and Previous Symbols: N/A
• Entrez ID: 7044
• UniProt: O00292
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
• UniProt Summary: Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18364
• Expression level (log2 read counts): -5.01

Expression Distribution

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LEFTY2 Expression in NALM6 Cells: -5.01