LILRB1
Gene Information
- Official Symbol: LILRB1
- Official Name: leukocyte immunoglobulin like receptor B1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10859
- UniProt: Q8NHL6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. {ECO:0000269|PubMed:11907092, ECO:0000269|PubMed:9285411, ECO:0000269|PubMed:9842885}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| regulation of gamma-delta T cell activation involved in immune response |
| negative regulation of interferon-beta secretion |
| positive regulation of gamma-delta T cell activation involved in immune response |
| HLA-A specific inhibitory MHC class I receptor activity |
| negative regulation of interleukin-10 secretion |
| HLA-B specific inhibitory MHC class I receptor activity |
| negative regulation of transforming growth factor-beta secretion |
| MHC class Ib protein complex binding |
| Fc receptor mediated inhibitory signaling pathway |
| negative regulation of interleukin-12 secretion |
| negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| regulation of transforming growth factor-beta secretion |
| negative regulation of interferon-gamma biosynthetic process |
| MHC class Ib receptor activity |
| negative regulation of serotonin secretion |
| T cell proliferation involved in immune response |
| regulation of interferon-beta secretion |
| positive regulation of gamma-delta T cell activation |
| MHC class I receptor activity |
| negative regulation of osteoclast development |
| MHC class Ib protein binding |
| regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| negative regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of dendritic cell differentiation |
| negative regulation of cytokine secretion involved in immune response |
| immune response-inhibiting cell surface receptor signaling pathway |
| negative regulation of T cell mediated cytotoxicity |
| regulation of gamma-delta T cell activation |
| regulation of serotonin secretion |
| negative regulation of dendritic cell apoptotic process |
| negative regulation of tumor necrosis factor biosynthetic process |
| regulation of interleukin-12 secretion |
| immune response-inhibiting signal transduction |
| interferon-gamma secretion |
| positive regulation of macrophage cytokine production |
| regulation of interleukin-10 secretion |
| negative regulation of bone development |
| regulation of dendritic cell apoptotic process |
| positive regulation of cytolysis |
| regulation of osteoclast development |
| regulation of dendritic cell differentiation |
| negative regulation of interferon-beta production |
| regulation of macrophage cytokine production |
| negative regulation of natural killer cell mediated cytotoxicity |
| regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of natural killer cell mediated immunity |
| regulation of cytokine secretion involved in immune response |
| negative regulation of interleukin-12 production |
| regulation of cytolysis |
| regulation of interferon-gamma biosynthetic process |
| negative regulation of interleukin-10 production |
| negative regulation of leukocyte mediated cytotoxicity |
| interferon-gamma production |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| MHC class I protein binding |
| negative regulation of T cell mediated immunity |
| protein phosphatase 1 binding |
| negative regulation of cell killing |
| negative regulation of neurotransmitter transport |
| regulation of bone development |
| negative regulation of cytokine production involved in immune response |
| positive regulation of defense response to virus by host |
| negative regulation of osteoclast differentiation |
| regulation of tumor necrosis factor biosynthetic process |
| negative regulation of cytokine biosynthetic process |
| dendritic cell differentiation |
| negative regulation of interferon-gamma production |
| regulation of T cell mediated cytotoxicity |
| negative regulation of production of molecular mediator of immune response |
| SH2 domain binding |
| regulation of defense response to virus by host |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of alpha-beta T cell activation |
| T cell proliferation |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of natural killer cell mediated cytotoxicity |
| negative regulation of endocytosis |
| regulation of natural killer cell mediated immunity |
| negative regulation of adaptive immune response |
| negative regulation of type I interferon production |
| negative regulation of myeloid leukocyte differentiation |
| negative regulation of leukocyte apoptotic process |
| regulation of interferon-beta production |
| cytokine secretion |
| negative regulation of leukocyte mediated immunity |
| regulation of interleukin-10 production |
| positive regulation of cytokine production involved in immune response |
| regulation of interleukin-12 production |
| negative regulation of innate immune response |
| negative regulation of tumor necrosis factor production |
| negative regulation of T cell proliferation |
| negative regulation of calcium ion transport |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| receptor internalization |
| T cell activation involved in immune response |
| regulation of osteoclast differentiation |
| negative regulation of cytokine secretion |
| regulation of T cell mediated immunity |
| regulation of defense response to virus |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of myeloid cell differentiation |
| regulation of leukocyte mediated cytotoxicity |
| negative regulation of leukocyte proliferation |
| amyloid-beta binding |
| regulation of leukocyte apoptotic process |
| lymphocyte proliferation |
| regulation of cytokine production involved in immune response |
| mononuclear cell proliferation |
| regulation of alpha-beta T cell activation |
| negative regulation of response to biotic stimulus |
| positive regulation of production of molecular mediator of immune response |
| leukocyte proliferation |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| regulation of cell killing |
| receptor metabolic process |
| regulation of cytokine biosynthetic process |
| lymphocyte activation involved in immune response |
| negative regulation of T cell activation |
| regulation of myeloid leukocyte differentiation |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of type I interferon production |
| negative regulation of protein secretion |
| negative regulation of hemopoiesis |
| negative regulation of peptide secretion |
| regulation of production of molecular mediator of immune response |
| regulation of neurotransmitter transport |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of ion transport |
| regulation of tumor necrosis factor production |
| negative regulation of immune response |
| cytokine production |
| regulation of lymphocyte mediated immunity |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of T cell proliferation |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of adaptive immune response |
| protein localization to extracellular region |
| peptide secretion |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| negative regulation of protein transport |
| cellular response to lipopolysaccharide |
| negative regulation of establishment of protein localization |
| defense response to virus |
| cellular response to molecule of bacterial origin |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of endocytosis |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| cellular response to biotic stimulus |
| negative regulation of multi-organism process |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of myeloid cell differentiation |
| negative regulation of secretion |
| T cell activation |
| receptor-mediated endocytosis |
| regulation of calcium ion transport |
| positive regulation of cell-cell adhesion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| response to virus |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| leukocyte differentiation |
| negative regulation of cell development |
| positive regulation of lymphocyte activation |
| negative regulation of response to external stimulus |
| lymphocyte activation |
| regulation of metal ion transport |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of protein secretion |
| regulation of immune effector process |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of lymphocyte activation |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| regulation of vesicle-mediated transport |
| cell population proliferation |
| endocytosis |
| hemopoiesis |
| negative regulation of cell cycle |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| negative regulation of cell population proliferation |
| import into cell |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of secretion |
| response to lipid |
| positive regulation of immune response |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| defense response to other organism |
| negative regulation of cell death |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Q15 2.7μM R02 exp79 | 1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10617
- Expression level (log2 read counts): 2.97
Expression Distribution
LILRB1 Expression in NALM6 Cells: 2.97
