LMO4
Gene Information
- Official Symbol: LMO4
- Official Name: LIM domain only 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 8543
- UniProt: P61968
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Probable transcriptional factor. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| LIM |
GO Terms
| regulation of cell fate specification |
| spinal cord association neuron differentiation |
| ventral spinal cord interneuron differentiation |
| dorsal spinal cord development |
| enhancer sequence-specific DNA binding |
| regulation of cell fate commitment |
| spinal cord motor neuron differentiation |
| cell leading edge |
| thymus development |
| ventral spinal cord development |
| cell differentiation in spinal cord |
| ventricular septum development |
| neural tube closure |
| tube closure |
| primary neural tube formation |
| neural tube formation |
| spinal cord development |
| cardiac septum development |
| embryonic epithelial tube formation |
| cardiac ventricle development |
| negative regulation of protein complex assembly |
| epithelial tube formation |
| morphogenesis of embryonic epithelium |
| tube formation |
| neural tube development |
| cardiac chamber development |
| central nervous system neuron differentiation |
| transcription factor complex |
| epithelial tube morphogenesis |
| transcription factor binding |
| gland development |
| morphogenesis of an epithelium |
| regulation of protein complex assembly |
| transcription by RNA polymerase II |
| heart development |
| tissue morphogenesis |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| regulation of cell activation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| positive regulation of transferase activity |
| DNA-binding transcription factor activity |
| negative regulation of cellular component organization |
| tube development |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of phosphorylation |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of catalytic activity |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 2μM R07 exp306 | 1.73 |
| I-BRD9 4μM R07 exp365 | 2.31 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GOLGA6L1 | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15624
- Expression level (log2 read counts): 4.86
Expression Distribution
LMO4 Expression in NALM6 Cells: 4.86
