LMOD1
Gene Information
- Official Symbol: LMOD1
- Official Name: leiomodin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 25802
- UniProt: P29536
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates nucleation of actin filaments. {ECO:0000269|PubMed:26370058}.
Pfam Domains GO Terms
Pfam Domains
| Tropomodulin |
GO Terms
| pointed-end actin filament capping |
| tropomyosin binding |
| striated muscle thin filament |
| myofibril |
| actin nucleation |
| actin filament capping |
| negative regulation of actin filament depolymerization |
| sarcomere |
| regulation of actin filament depolymerization |
| negative regulation of actin filament polymerization |
| negative regulation of protein depolymerization |
| negative regulation of protein polymerization |
| myofibril assembly |
| negative regulation of protein complex disassembly |
| actin filament |
| regulation of protein depolymerization |
| positive regulation of actin filament polymerization |
| cellular component assembly involved in morphogenesis |
| regulation of protein complex disassembly |
| actomyosin structure organization |
| positive regulation of protein polymerization |
| negative regulation of supramolecular fiber organization |
| negative regulation of protein complex assembly |
| striated muscle cell development |
| negative regulation of cytoskeleton organization |
| muscle cell development |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| striated muscle cell differentiation |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| muscle cell differentiation |
| positive regulation of protein complex assembly |
| muscle contraction |
| regulation of actin filament organization |
| actin binding |
| muscle system process |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| muscle structure development |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| actin filament-based process |
| positive regulation of organelle organization |
| negative regulation of cellular component organization |
| organelle assembly |
| cellular component morphogenesis |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular component biogenesis |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| cell development |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Salubrinal 20μM R07 exp399 | -2.02 |
| Salinomycin 3.5μM R08 exp521 | -1.95 |
| CI-1040 9.5μM R08 exp472 | -1.82 |
| VHL-ligand-1 20μM R07 exp421 | 1.9 |
| Vinorelbine 0.001μM R05 exp249 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3105
- Expression level (log2 read counts): -2.28
Expression Distribution
LMOD1 Expression in NALM6 Cells: -2.28
