LPAR3
Gene Information
- Official Symbol: LPAR3
- Official Name: lysophosphatidic acid receptor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 23566
- UniProt: Q9UBY5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| lysophosphatidic acid receptor activity |
| bleb assembly |
| positive regulation of collateral sprouting |
| regulation of collateral sprouting |
| G-protein alpha-subunit binding |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| positive regulation of axonogenesis |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| phospholipid binding |
| regulation of extent of cell growth |
| positive regulation of calcium ion transport |
| lipid binding |
| activation of MAPK activity |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| regulation of cell size |
| regulation of axonogenesis |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| positive regulation of growth |
| positive regulation of MAP kinase activity |
| positive regulation of ion transport |
| positive regulation of neuron projection development |
| positive regulation of cytosolic calcium ion concentration |
| axon |
| regulation of cell morphogenesis involved in differentiation |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| regulation of developmental growth |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| positive regulation of neuron differentiation |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of metal ion transport |
| regulation of cell growth |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| plasma membrane bounded cell projection assembly |
| calcium ion homeostasis |
| cell projection assembly |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| divalent inorganic cation homeostasis |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| positive regulation of kinase activity |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| cation homeostasis |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| chemical homeostasis |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| EPZ-5676 30μM R05 exp233 | -1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14300
- Expression level (log2 read counts): 0.99
Expression Distribution
LPAR3 Expression in NALM6 Cells: 0.99
