LPL
Gene Information
- Official Symbol: LPL
- Official Name: lipoprotein lipase
- Aliases and Previous Symbols: N/A
- Entrez ID: 4023
- UniProt: P06858
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008].
- UniProt Summary: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250, ECO:0000269|PubMed:11342582, ECO:0000269|PubMed:27578112}.
Pfam Domains GO Terms
Pfam Domains
| Lipase |
| Abhydrolase 6 |
| PLAT |
GO Terms
| triglyceride binding |
| lipoprotein lipase activity |
| low-density lipoprotein particle mediated signaling |
| lipoprotein particle mediated signaling |
| positive regulation of chemokine (C-C motif) ligand 2 secretion |
| regulation of chemokine (C-C motif) ligand 2 secretion |
| positive regulation of cholesterol storage |
| positive regulation of sequestering of triglyceride |
| lipoprotein particle binding |
| chylomicron remodeling |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| very-low-density lipoprotein particle remodeling |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| regulation of sequestering of triglyceride |
| chylomicron |
| protein membrane anchor |
| triglyceride-rich lipoprotein particle remodeling |
| positive regulation of chemokine secretion |
| regulation of cholesterol storage |
| apolipoprotein binding |
| heparan sulfate proteoglycan binding |
| regulation of chemokine secretion |
| positive regulation of macrophage derived foam cell differentiation |
| phospholipase activity |
| high-density lipoprotein particle remodeling |
| cellular response to low-density lipoprotein particle stimulus |
| triglyceride biosynthetic process |
| very-low-density lipoprotein particle |
| positive regulation of tumor necrosis factor secretion |
| positive regulation of lipid storage |
| regulation of lipoprotein lipase activity |
| neutral lipid biosynthetic process |
| acylglycerol biosynthetic process |
| triglyceride lipase activity |
| lipase activity |
| triglyceride catabolic process |
| response to lipoprotein particle |
| plasma lipoprotein particle remodeling |
| protein-lipid complex remodeling |
| cellular response to lipoprotein particle stimulus |
| protein-containing complex remodeling |
| regulation of tumor necrosis factor secretion |
| regulation of macrophage derived foam cell differentiation |
| positive regulation of interleukin-6 secretion |
| positive regulation of interleukin-1 beta secretion |
| triglyceride homeostasis |
| neutral lipid catabolic process |
| acylglycerol catabolic process |
| acylglycerol homeostasis |
| negative regulation of cellular response to insulin stimulus |
| positive regulation of interleukin-1 secretion |
| plasma lipoprotein particle organization |
| regulation of lipid storage |
| regulation of interleukin-1 beta secretion |
| protein-lipid complex subunit organization |
| response to cold |
| positive regulation of interleukin-1 beta production |
| glycerolipid catabolic process |
| regulation of interleukin-1 secretion |
| cellular response to fatty acid |
| positive regulation of chemokine production |
| positive regulation of interleukin-1 production |
| positive regulation of fat cell differentiation |
| cellular response to nutrient |
| regulation of plasma lipoprotein particle levels |
| regulation of cellular response to insulin stimulus |
| triglyceride metabolic process |
| regulation of chemokine production |
| cholesterol homeostasis |
| sterol homeostasis |
| regulation of interleukin-1 beta production |
| positive regulation of lipid localization |
| response to fatty acid |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of interleukin-1 production |
| positive regulation of interleukin-6 production |
| regulation of lipase activity |
| acylglycerol metabolic process |
| neutral lipid metabolic process |
| retinoid metabolic process |
| diterpenoid metabolic process |
| fatty acid biosynthetic process |
| terpenoid metabolic process |
| regulation of fat cell differentiation |
| lipid homeostasis |
| regulation of lipid localization |
| isoprenoid metabolic process |
| response to glucose |
| positive regulation of cytokine secretion |
| positive regulation of inflammatory response |
| regulation of interleukin-6 production |
| response to hexose |
| regulation of tumor necrosis factor production |
| response to monosaccharide |
| regulation of tumor necrosis factor superfamily cytokine production |
| heparin binding |
| response to carbohydrate |
| response to temperature stimulus |
| monocarboxylic acid biosynthetic process |
| cellular lipid catabolic process |
| regulation of cytokine secretion |
| cellular response to acid chemical |
| response to nutrient |
| glycerolipid biosynthetic process |
| cellular response to nutrient levels |
| cellular response to extracellular stimulus |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| lipid catabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| fatty acid metabolic process |
| cellular response to external stimulus |
| signaling receptor binding |
| regulation of inflammatory response |
| response to acid chemical |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| extracellular structure organization |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| regulation of peptide secretion |
| response to nutrient levels |
| cellular response to lipid |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| positive regulation of response to external stimulus |
| cell surface |
| response to bacterium |
| regulation of cytokine production |
| regulation of protein transport |
| calcium ion binding |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| response to lipid |
| protein homodimerization activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| cellular lipid metabolic process |
| positive regulation of cell differentiation |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| response to abiotic stimulus |
| lipid metabolic process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| extracellular space |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15581
- Expression level (log2 read counts): -7.68
Expression Distribution
LPL Expression in NALM6 Cells: -7.68
