UniProt Summary: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
I-set
LRR 4
ig
GO Terms
otolith morphogenesis
otolith development
inner ear morphogenesis
ear morphogenesis
cytoplasmic vesicle membrane
inner ear development
ear development
extracellular matrix
sensory organ morphogenesis
embryonic organ morphogenesis
embryonic organ development
sensory organ development
embryonic morphogenesis
animal organ morphogenesis
embryo development
extracellular space
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739