LRRFIP2
Gene Information
- Official Symbol: LRRFIP2
- Official Name: LRR binding FLII interacting protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9209
- UniProt: Q9Y608
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017].
- UniProt Summary: May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269|PubMed:15677333, ECO:0000269|PubMed:19265123}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11029
- Expression level (log2 read counts): 6.36
LRRFIP2 Expression in NALM6 Cells: 6.36
