LUM
Gene Information
- Official Symbol: LUM
- Official Name: lumican
- Aliases and Previous Symbols: N/A
- Entrez ID: 4060
- UniProt: P51884
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| LRRNT |
| LRR 4 |
GO Terms
| fibrillar collagen trimer |
| positive regulation of transforming growth factor beta1 production |
| regulation of transforming growth factor beta1 production |
| keratan sulfate catabolic process |
| extracellular matrix structural constituent conferring compression resistance |
| positive regulation of transforming growth factor beta production |
| keratan sulfate biosynthetic process |
| keratan sulfate metabolic process |
| regulation of transforming growth factor beta production |
| collagen fibril organization |
| sulfur compound catabolic process |
| glycosaminoglycan catabolic process |
| collagen binding |
| aminoglycan catabolic process |
| lysosomal lumen |
| Golgi lumen |
| glycosaminoglycan biosynthetic process |
| mucopolysaccharide metabolic process |
| aminoglycan biosynthetic process |
| extracellular matrix structural constituent |
| glycosaminoglycan metabolic process |
| aminoglycan metabolic process |
| cartilage development |
| sulfur compound biosynthetic process |
| carbohydrate derivative catabolic process |
| visual perception |
| connective tissue development |
| sensory perception of light stimulus |
| extracellular matrix |
| extracellular matrix organization |
| collagen-containing extracellular matrix |
| sulfur compound metabolic process |
| extracellular structure organization |
| positive regulation of cytokine production |
| supramolecular fiber organization |
| skeletal system development |
| response to growth factor |
| carbohydrate derivative biosynthetic process |
| regulation of cytokine production |
| response to organic cyclic compound |
| sensory perception |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| positive regulation of transcription by RNA polymerase II |
| nervous system process |
| organonitrogen compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| extracellular space |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14874
- Expression level (log2 read counts): -7.68
Expression Distribution
LUM Expression in NALM6 Cells: -7.68
