LYZ
Gene Information
- Official Symbol: LYZ
- Official Name: lysozyme
- Aliases and Previous Symbols: N/A
- Entrez ID: 4069
- UniProt: P61626
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014].
- UniProt Summary: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13535
- Expression level (log2 read counts): 1.81
LYZ Expression in NALM6 Cells: 1.81
