MAP1LC3B2
Gene Information
- Official Symbol: MAP1LC3B2
- Official Name: microtubule associated protein 1 light chain 3 beta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 643246
- UniProt: A6NCE7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7064
- Expression level (log2 read counts): 3.02
MAP1LC3B2 Expression in NALM6 Cells: 3.02
