MAP3K10
Gene Information
- Official Symbol: MAP3K10
- Official Name: mitogen-activated protein kinase kinase kinase 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 4294
- UniProt: Q02779
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activates the JUN N-terminal pathway. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| Pkinase |
| SH3 1 |
| Pkinase Tyr |
GO Terms
| JUN kinase kinase kinase activity |
| activation of JNKK activity |
| bHLH transcription factor binding |
| activation of JUN kinase activity |
| activation of MAPKK activity |
| positive regulation of JUN kinase activity |
| smoothened signaling pathway |
| JNK cascade |
| peptidyl-threonine phosphorylation |
| regulation of JUN kinase activity |
| peptidyl-threonine modification |
| stress-activated MAPK cascade |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| activation of MAPK activity |
| negative regulation of DNA-binding transcription factor activity |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| peptidyl-serine phosphorylation |
| regulation of JNK cascade |
| protein autophosphorylation |
| peptidyl-serine modification |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| transcription corepressor activity |
| positive regulation of MAP kinase activity |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| regulation of DNA-binding transcription factor activity |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| positive regulation of cell death |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| apoptotic process |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| positive regulation of phosphorylation |
| cell death |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| EPZ-5676 30μM R05 exp233 | 1.77 |
| Deguelin 0.15μM R05 exp209 | 2.13 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4800
- Expression level (log2 read counts): 3.62
Expression Distribution
MAP3K10 Expression in NALM6 Cells: 3.62
