MAP3K3
Gene Information
- Official Symbol: MAP3K3
- Official Name: mitogen-activated protein kinase kinase kinase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 4215
- UniProt: Q99759
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}.
Pfam Domains GO Terms
Pfam Domains
| PB1 |
| Pkinase |
| Pkinase Tyr |
GO Terms
| positive regulation of cell proliferation in bone marrow |
| regulation of cell proliferation in bone marrow |
| negative regulation of cellular senescence |
| MAP kinase kinase kinase activity |
| positive regulation of cell migration involved in sprouting angiogenesis |
| negative regulation of cell aging |
| positive regulation of p38MAPK cascade |
| regulation of cell migration involved in sprouting angiogenesis |
| positive regulation of sprouting angiogenesis |
| regulation of p38MAPK cascade |
| regulation of cellular senescence |
| regulation of cell aging |
| activation of MAPKK activity |
| positive regulation of blood vessel endothelial cell migration |
| regulation of sprouting angiogenesis |
| regulation of blood vessel endothelial cell migration |
| interleukin-1-mediated signaling pathway |
| positive regulation of endothelial cell migration |
| positive regulation of epithelial cell migration |
| stress-activated protein kinase signaling cascade |
| regulation of endothelial cell migration |
| positive regulation of angiogenesis |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| cellular response to interleukin-1 |
| positive regulation of vasculature development |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| protein autophosphorylation |
| response to interleukin-1 |
| regulation of epithelial cell migration |
| regulation of stress-activated MAPK cascade |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| positive regulation of MAP kinase activity |
| regulation of angiogenesis |
| regulation of vasculature development |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| protein serine/threonine kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| blood vessel development |
| positive regulation of cell migration |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6345
- Expression level (log2 read counts): 5.42
Expression Distribution
MAP3K3 Expression in NALM6 Cells: 5.42
