MAPK8IP3
Gene Information
- Official Symbol: MAPK8IP3
- Official Name: mitogen-activated protein kinase 8 interacting protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 23162
- UniProt: Q9UPT6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Jnk-SapK ap N |
GO Terms
| JUN kinase binding |
| MAP-kinase scaffold activity |
| protein localization to presynapse |
| anterograde axonal protein transport |
| axo-dendritic protein transport |
| receptor signaling complex adaptor activity |
| axon regeneration |
| neuron projection regeneration |
| activation of JUN kinase activity |
| kinesin binding |
| anterograde axonal transport |
| response to axon injury |
| axonal transport |
| axon cytoplasm |
| protein localization to synapse |
| axo-dendritic transport |
| protein transport along microtubule |
| microtubule-based protein transport |
| cell body |
| positive regulation of JUN kinase activity |
| JNK cascade |
| regulation of JUN kinase activity |
| stress-activated MAPK cascade |
| growth cone |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| activation of MAPK activity |
| regeneration |
| transport along microtubule |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| regulation of JNK cascade |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cytoplasmic vesicle |
| positive regulation of MAP kinase activity |
| microtubule-based movement |
| axon |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| axon development |
| dendrite |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| response to wounding |
| positive regulation of kinase activity |
| Golgi membrane |
| positive regulation of transferase activity |
| neuron projection development |
| microtubule-based process |
| perinuclear region of cytoplasm |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| neuron development |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| intracellular protein transport |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCCP 0.1μM R00 exp10 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5835
- Expression level (log2 read counts): 7.64
Expression Distribution
MAPK8IP3 Expression in NALM6 Cells: 7.64
