UniProt Summary: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Pfam DomainsGO Terms
Pfam Domains
MARCKS
GO Terms
germinal vesicle
actin crosslink formation
actin filament bundle
protein kinase C binding
actin filament bundle assembly
actin filament bundle organization
cell cortex
calmodulin binding
actin filament binding
actin cytoskeleton
actin filament organization
protein homooligomerization
focal adhesion
supramolecular fiber organization
centrosome
actin cytoskeleton organization
protein complex oligomerization
actin filament-based process
identical protein binding
cytoskeleton organization
protein-containing complex assembly
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739