Entrez Summary: This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Pfam DomainsGO Terms
Pfam Domains
Globin
GO Terms
slow-twitch skeletal muscle fiber contraction
twitch skeletal muscle contraction
voluntary skeletal muscle contraction
enucleate erythrocyte differentiation
oxygen carrier activity
oxygen transport
gas transport
brown fat cell differentiation
skeletal muscle contraction
oxygen binding
multicellular organismal movement
musculoskeletal movement
erythrocyte differentiation
erythrocyte homeostasis
fat cell differentiation
myeloid cell homeostasis
striated muscle contraction
response to hydrogen peroxide
heme binding
drug transport
response to reactive oxygen species
homeostasis of number of cells
myeloid cell differentiation
muscle contraction
muscle system process
response to antibiotic
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
response to oxidative stress
response to toxic substance
heart development
response to inorganic substance
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
circulatory system development
response to hormone
response to drug
response to abiotic stimulus
response to endogenous stimulus
response to oxygen-containing compound
homeostatic process
system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)