MBP
Gene Information
- Official Symbol: MBP
- Official Name: myelin basic protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 4155
- UniProt: P02686
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Myelin MBP |
GO Terms
| maintenance of permeability of blood-brain barrier |
| positive regulation of metalloendopeptidase activity |
| regulation of chemokine (C-C motif) ligand 2 secretion |
| compact myelin |
| internode region of axon |
| positive regulation of chemokine (C-C motif) ligand 2 secretion |
| regulation of metalloendopeptidase activity |
| positive regulation of metallopeptidase activity |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| structural constituent of myelin sheath |
| regulation of cell-cell adhesion involved in gastrulation |
| negative regulation of heterotypic cell-cell adhesion |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| regulation of metallopeptidase activity |
| positive regulation of chemokine secretion |
| regulation of chemokine secretion |
| regulation of heterotypic cell-cell adhesion |
| positive regulation of interleukin-6 secretion |
| myelin sheath |
| regulation of gastrulation |
| cell periphery |
| substantia nigra development |
| positive regulation of chemokine production |
| neural nucleus development |
| regulation of chemokine production |
| midbrain development |
| positive regulation of interleukin-6 production |
| protease binding |
| myelination |
| axon ensheathment |
| ensheathment of neurons |
| regulation of embryonic development |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| sensory perception of sound |
| sensory perception of mechanical stimulus |
| positive regulation of endopeptidase activity |
| negative regulation of cell-cell adhesion |
| positive regulation of peptidase activity |
| calmodulin binding |
| regulation of cytokine secretion |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| positive regulation of peptide secretion |
| positive regulation of proteolysis |
| MAPK cascade |
| neuronal cell body |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| regulation of endopeptidase activity |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| positive regulation of protein transport |
| positive regulation of secretion |
| trans-synaptic signaling |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of protein secretion |
| regulation of peptide secretion |
| response to toxic substance |
| protein-containing complex |
| cell surface |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| head development |
| regulation of secretion |
| membrane organization |
| sensory perception |
| protein phosphorylation |
| central nervous system development |
| positive regulation of transport |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| regulation of hydrolase activity |
| phosphorylation |
| nervous system process |
| positive regulation of catalytic activity |
| positive regulation of cellular protein metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of transport |
| immune response |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16616
- Expression level (log2 read counts): 6.42
Expression Distribution
MBP Expression in NALM6 Cells: 6.42
