MC3R
Gene Information
- Official Symbol: MC3R
- Official Name: melanocortin 3 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 4159
- UniProt: P41968
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008].
- UniProt Summary: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. {ECO:0000250|UniProtKB:P33033}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3097
- Expression level (log2 read counts): -7.68
MC3R Expression in NALM6 Cells: -7.68
