Pfam Domains GO Terms
| Med6 |
| core mediator complex |
| RNA polymerase II preinitiation complex assembly |
| transcription preinitiation complex assembly |
| mediator complex |
| transcription initiation from RNA polymerase II promoter |
| protein-DNA complex assembly |
| DNA-templated transcription, initiation |
| protein-DNA complex subunit organization |
| transcription coactivator activity |
| transcription factor binding |
| transcription by RNA polymerase II |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| cellular protein-containing complex assembly |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Hypoxia 5%O2 R04 exp191 | -1.79 |
| Cadmium 60μM R08 exp462 | -1.75 |
| CCT251545 20μM R07 exp326 | 1.73 |
| 39°C R06 exp303 | 1.83 |
| Hinokiflavone 12μM R08 exp487 | 2.37 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 24/28 |
| blood | 27/28 |
| bone | 23/25 |
| breast | 23/33 |
| central nervous system | 45/56 |
| cervix | 3/4 |
| colorectal | 16/17 |
| esophagus | 8/13 |
| fibroblast | 1/1 |
| gastric | 9/15 |
| kidney | 19/21 |
| liver | 14/20 |
| lung | 55/75 |
| lymphocyte | 10/14 |
| ovary | 18/26 |
| pancreas | 18/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 5/7 |
| thyroid | 2/2 |
| upper aerodigestive | 13/22 |
| urinary tract | 23/29 |
| uterus | 5/5 |
Expression Distribution