MEX3C
Gene Information
- Official Symbol: MEX3C
- Official Name: mex-3 RNA binding family member C
- Aliases and Previous Symbols: N/A
- Entrez ID: 51320
- UniProt: Q5U5Q3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009].
- UniProt Summary: E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2278
- Expression level (log2 read counts): 6.32
MEX3C Expression in NALM6 Cells: 6.32
