MGP
Gene Information
- Official Symbol: MGP
- Official Name: matrix Gla protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 4256
- UniProt: P08493
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016].
- UniProt Summary: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17310
- Expression level (log2 read counts): 2.02
MGP Expression in NALM6 Cells: 2.02
