UniProt Summary: Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex. {ECO:0000269|PubMed:23015756, ECO:0000269|PubMed:23045692}.
Pfam DomainsGO Terms
Pfam Domains
MIT
GO Terms
midbody abscission
viral budding via host ESCRT complex
mitotic cytokinetic process
viral budding
multivesicular body sorting pathway
cytokinetic process
virion assembly
extrinsic component of membrane
mitotic cytokinesis
phosphatidylinositol binding
cytoskeleton-dependent cytokinesis
cytokinesis
negative regulation of protein binding
late endosome membrane
midbody
negative regulation of binding
viral life cycle
regulation of protein binding
protein domain specific binding
regulation of binding
cell division
mitotic cell cycle process
mitotic cell cycle
intracellular membrane-bounded organelle
viral process
symbiotic process
interspecies interaction between organisms
membrane organization
protein homodimerization activity
cell cycle process
negative regulation of molecular function
cell cycle
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739