MMP11
Gene Information
- Official Symbol: MMP11
- Official Name: matrix metallopeptidase 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 4320
- UniProt: P24347
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008].
- UniProt Summary: May play an important role in the progression of epithelial malignancies.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7772
- Expression level (log2 read counts): 2.81
MMP11 Expression in NALM6 Cells: 2.81
