UniProt Summary: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Peptidase M10
PG binding 1
Hemopexin
GO Terms
extrinsic component of endoplasmic reticulum membrane
collagen catabolic process
collagen metabolic process
metalloendopeptidase activity
extracellular matrix
extracellular matrix organization
extracellular structure organization
zinc ion binding
proteolysis
extracellular space
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739