MNDA
Gene Information
- Official Symbol: MNDA
- Official Name: myeloid cell nuclear differentiation antigen
- Aliases and Previous Symbols: N/A
- Entrez ID: 4332
- UniProt: P41218
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
Pfam Domains GO Terms
Pfam Domains
| PAAD DAPIN |
| HIN |
GO Terms
| negative regulation of B cell proliferation |
| cellular response to interferon-beta |
| response to interferon-beta |
| negative regulation of B cell activation |
| positive regulation of interleukin-1 beta production |
| cellular defense response |
| positive regulation of interleukin-1 production |
| regulation of B cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| regulation of interleukin-1 beta production |
| azurophil granule lumen |
| regulation of interleukin-1 production |
| double-stranded DNA binding |
| ficolin-1-rich granule lumen |
| B cell receptor signaling pathway |
| negative regulation of lymphocyte activation |
| negative regulation of leukocyte activation |
| negative regulation of cell activation |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| activation of innate immune response |
| antigen receptor-mediated signaling pathway |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| regulation of response to biotic stimulus |
| myeloid cell activation involved in immune response |
| immune response-activating signal transduction |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| exocytosis |
| nucleolus |
| positive regulation of immune response |
| leukocyte activation |
| secretion by cell |
| cellular response to cytokine stimulus |
| export from cell |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| secretion |
| positive regulation of immune system process |
| regulation of immune response |
| defense response |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.474 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14605
- Expression level (log2 read counts): -7.68
Expression Distribution
MNDA Expression in NALM6 Cells: -7.68
