UniProt Summary: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}.
Pfam DomainsGO Terms
Pfam Domains
PDZ
SH3 2
Guanylate kin
SH3 1
L27
GO Terms
protein localization to adherens junction
MPP7-DLG1-LIN7 complex
protein localization to cell junction
signaling adaptor activity
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
molecular adaptor activity
adherens junction
cell-cell junction assembly
establishment of cell polarity
bicellular tight junction
cell-cell junction organization
cell junction assembly
establishment or maintenance of cell polarity
cell junction organization
protein domain specific binding
positive regulation of protein complex assembly
cadherin binding
regulation of protein complex assembly
protein heterodimerization activity
positive regulation of cellular component biogenesis
cell junction
regulation of cellular component biogenesis
positive regulation of cellular component organization
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)