Entrez Summary: This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance.
Pfam DomainsGO Terms
Pfam Domains
Mpv17 PMP22
GO Terms
glomerular basement membrane development
mitochondrial genome maintenance
glomerulus development
peroxisomal membrane
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
peroxisome organization
peroxisome
nephron development
cellular response to reactive oxygen species
regulation of reactive oxygen species metabolic process
inner ear development
response to reactive oxygen species
ear development
cellular response to oxidative stress
kidney development
renal system development
urogenital system development
extracellular matrix organization
protein targeting
extracellular structure organization
response to oxidative stress
mitochondrial inner membrane
establishment of protein localization to organelle
mitochondrion organization
sensory organ development
protein localization to organelle
molecular function
intracellular protein transport
cellular response to oxygen-containing compound
mitochondrion
protein transport
intracellular transport
peptide transport
response to oxygen-containing compound
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
homeostatic process
cellular response to stress
establishment of localization in cell
nitrogen compound transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739