MTHFD2L
Gene Information
- Official Symbol: MTHFD2L
- Official Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 441024
- UniProt: Q9H903
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| THF DHG CYH C |
| THF DHG CYH |
GO Terms
| histidine biosynthetic process |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| aromatic amino acid family biosynthetic process |
| methenyltetrahydrofolate cyclohydrolase activity |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| 10-formyltetrahydrofolate metabolic process |
| histidine metabolic process |
| tetrahydrofolate interconversion |
| imidazole-containing compound metabolic process |
| methionine biosynthetic process |
| methionine metabolic process |
| sulfur amino acid biosynthetic process |
| tetrahydrofolate metabolic process |
| folic acid metabolic process |
| aspartate family amino acid biosynthetic process |
| one-carbon metabolic process |
| folic acid-containing compound metabolic process |
| pteridine-containing compound metabolic process |
| aromatic amino acid family metabolic process |
| sulfur amino acid metabolic process |
| aspartate family amino acid metabolic process |
| alpha-amino acid biosynthetic process |
| cellular amino acid biosynthetic process |
| water-soluble vitamin metabolic process |
| dicarboxylic acid metabolic process |
| vitamin metabolic process |
| purine nucleotide biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| cellular modified amino acid metabolic process |
| alpha-amino acid metabolic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| cellular amino acid metabolic process |
| purine nucleotide metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| mitochondrial matrix |
| mitochondrial inner membrane |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| drug metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| cellular amide metabolic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Staurosporine 0.02μM R08 exp524 | -1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12520
- Expression level (log2 read counts): 4.78
Expression Distribution
MTHFD2L Expression in NALM6 Cells: 4.78
