Entrez Summary: This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
regulation of macrophage chemotaxis
regulation of macrophage migration
regulation of leukocyte chemotaxis
spindle
microtubule cytoskeleton
microtubule organizing center
regulation of leukocyte migration
regulation of chemotaxis
microtubule binding
microtubule
regulation of cell migration
nucleolus
regulation of cell motility
regulation of locomotion
Golgi apparatus
regulation of cellular component movement
regulation of response to external stimulus
mitochondrion
extracellular space
regulation of immune system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739