MYF5
Gene Information
- Official Symbol: MYF5
- Official Name: myogenic factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 4617
- UniProt: P13349
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Pfam Domains GO Terms
Pfam Domains
| HLH |
| Basic |
| Myf5 |
GO Terms
| positive regulation of skeletal muscle fiber development |
| regulation of skeletal muscle fiber development |
| muscle cell fate commitment |
| positive regulation of myoblast fusion |
| cartilage condensation |
| cell aggregation |
| regulation of myoblast fusion |
| positive regulation of myoblast differentiation |
| positive regulation of skeletal muscle tissue development |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| positive regulation of myotube differentiation |
| regulation of skeletal muscle tissue development |
| skeletal muscle cell differentiation |
| E-box binding |
| regulation of myoblast differentiation |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| somitogenesis |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| RNA polymerase II transcription factor complex |
| muscle tissue morphogenesis |
| somite development |
| positive regulation of muscle cell differentiation |
| muscle organ morphogenesis |
| embryonic skeletal system morphogenesis |
| segmentation |
| regulation of striated muscle cell differentiation |
| regulation of cell-matrix adhesion |
| skeletal muscle tissue development |
| embryonic skeletal system development |
| regulation of striated muscle tissue development |
| skeletal muscle organ development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| regulation of muscle cell differentiation |
| cartilage development |
| regulation of cell-substrate adhesion |
| anterior/posterior pattern specification |
| connective tissue development |
| skeletal system morphogenesis |
| muscle cell differentiation |
| cell fate commitment |
| ossification |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle organ development |
| muscle tissue development |
| camera-type eye development |
| regionalization |
| extracellular matrix organization |
| eye development |
| visual system development |
| sensory system development |
| extracellular structure organization |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| muscle structure development |
| protein heterodimerization activity |
| skeletal system development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of cell development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of cell adhesion |
| anatomical structure formation involved in morphogenesis |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of developmental process |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.04μM R03 exp98 | -1.74 |
| Lapatinib 5μM R01 exp47 | 1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6079
- Expression level (log2 read counts): -7.68
Expression Distribution
MYF5 Expression in NALM6 Cells: -7.68
