NACA
Gene Information
- Official Symbol: N/ACA
- Official Name: nascent polypeptide associated complex subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 4666
- UniProt: Q13765"|"E9PAV3|Q13765"
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016].
- UniProt Summary: N/A
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3651
- Expression level (log2 read counts): 8.42
NACA Expression in NALM6 Cells: 8.42
