NCF1
Gene Information
- Official Symbol: NCF1
- Official Name: neutrophil cytosolic factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 653361
- UniProt: P14598
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| PX |
| SH3 1 |
| p47 phox C |
GO Terms
| phagolysosome |
| positive regulation of epidermal growth factor-activated receptor activity |
| superoxide-generating NADPH oxidase activator activity |
| superoxide-generating NADPH oxidase activity |
| NADPH oxidase complex |
| superoxide anion generation |
| respiratory burst |
| positive regulation of p38MAPK cascade |
| regulation of epidermal growth factor-activated receptor activity |
| phosphatidylinositol-3,4-bisphosphate binding |
| positive regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of ERBB signaling pathway |
| positive regulation of signaling receptor activity |
| cellular response to cadmium ion |
| superoxide metabolic process |
| regulation of p38MAPK cascade |
| cellular defense response |
| positive regulation of protein tyrosine kinase activity |
| rough endoplasmic reticulum |
| response to cadmium ion |
| extrinsic component of membrane |
| vascular endothelial growth factor receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| cell redox homeostasis |
| electron transfer activity |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| phosphatidylinositol binding |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| antigen processing and presentation of peptide antigen via MHC class I |
| reactive oxygen species metabolic process |
| regulation of phosphatidylinositol 3-kinase signaling |
| SH3 domain binding |
| cellular response to reactive oxygen species |
| positive regulation of JNK cascade |
| protein targeting to membrane |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of signaling receptor activity |
| antigen processing and presentation of exogenous peptide antigen |
| electron transport chain |
| antigen processing and presentation of exogenous antigen |
| regulation of JNK cascade |
| antigen processing and presentation of peptide antigen |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to metal ion |
| response to reactive oxygen species |
| antigen processing and presentation |
| cellular response to inorganic substance |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| cellular response to oxidative stress |
| regulation of peptidyl-tyrosine phosphorylation |
| establishment of protein localization to membrane |
| protein targeting |
| response to metal ion |
| neuronal cell body |
| response to oxidative stress |
| dendrite |
| generation of precursor metabolites and energy |
| protein localization to membrane |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| innate immune response |
| regulation of protein kinase activity |
| regulation of kinase activity |
| cellular homeostasis |
| apoptotic process |
| defense response to other organism |
| oxidation-reduction process |
| regulation of transferase activity |
| Golgi apparatus |
| intracellular protein transport |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell death |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4901
- Expression level (log2 read counts): 1.68
Expression Distribution
NCF1 Expression in NALM6 Cells: 1.68
