NCKAP1
Gene Information
- Official Symbol: NCKAP1
- Official Name: NCK associated protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10787
- UniProt: Q9Y2A7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:P28660}.
Pfam Domains GO Terms
Pfam Domains
| Nckap1 |
GO Terms
| positive regulation of Arp2/3 complex-mediated actin nucleation |
| SCAR complex |
| positive regulation of actin nucleation |
| regulation of Arp2/3 complex-mediated actin nucleation |
| positive regulation of lamellipodium assembly |
| Rac protein signal transduction |
| lamellipodium membrane |
| regulation of actin nucleation |
| positive regulation of lamellipodium organization |
| regulation of lamellipodium assembly |
| filamentous actin |
| regulation of lamellipodium organization |
| cortical actin cytoskeleton organization |
| cortical cytoskeleton organization |
| Rac GTPase binding |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of actin filament polymerization |
| ruffle |
| positive regulation of plasma membrane bounded cell projection assembly |
| positive regulation of protein polymerization |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| Fc receptor signaling pathway |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| small GTPase mediated signal transduction |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| focal adhesion |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| cell projection assembly |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| cell part morphogenesis |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| viral process |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| symbiotic process |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| positive regulation of immune response |
| apoptotic process |
| regulation of cellular component biogenesis |
| cell migration |
| central nervous system development |
| neuron differentiation |
| programmed cell death |
| localization of cell |
| cell motility |
| cell death |
| immune effector process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| generation of neurons |
| movement of cell or subcellular component |
| neurogenesis |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| AICAR 240μM R05 exp211 | 2.64 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 78/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 10/28 |
| blood | 0/28 |
| bone | 2/26 |
| breast | 2/33 |
| central nervous system | 7/56 |
| cervix | 0/4 |
| colorectal | 4/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 2/21 |
| liver | 6/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 6/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 2/9 |
| thyroid | 1/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 4/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18120
- Expression level (log2 read counts): 3.7
Expression Distribution
NCKAP1 Expression in NALM6 Cells: 3.7
