NDRG2
Gene Information
- Official Symbol: NDRG2
- Official Name: NDRG family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 57447
- UniProt: Q9UN36
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Abhydrolase 6 |
| Ndr |
GO Terms
| regulation of platelet-derived growth factor production |
| regulation of vascular endothelial growth factor production |
| substantia nigra development |
| negative regulation of smooth muscle cell proliferation |
| neural nucleus development |
| negative regulation of ERK1 and ERK2 cascade |
| midbrain development |
| growth cone |
| regulation of smooth muscle cell proliferation |
| negative regulation of MAPK cascade |
| negative regulation of cytokine production |
| regulation of ERK1 and ERK2 cascade |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| negative regulation of protein phosphorylation |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| negative regulation of phosphorylation |
| negative regulation of intracellular signal transduction |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| brain development |
| regulation of MAPK cascade |
| molecular function |
| head development |
| central nervous system development |
| Golgi apparatus |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RUVBL2 | 0.477 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5798
- Expression level (log2 read counts): 2.59
Expression Distribution
NDRG2 Expression in NALM6 Cells: 2.59
