Entrez Summary: This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010].
UniProt Summary: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. {ECO:0000250, ECO:0000269|PubMed:15317751}.
Pfam DomainsGO Terms
Pfam Domains
DUF803
EamA
GO Terms
magnesium ion transmembrane transporter activity
magnesium ion transmembrane transport
magnesium ion transport
divalent metal ion transport
divalent inorganic cation transport
inorganic cation transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739