NLRC5
Gene Information
- Official Symbol: NLRC5
- Official Name: NLR family CARD domain containing 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 84166
- UniProt: Q86WI3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| NACHT |
| LRR 4 |
GO Terms
| positive regulation of MHC class I biosynthetic process |
| positive regulation of response to interferon-gamma |
| positive regulation of interferon-gamma-mediated signaling pathway |
| regulation of MHC class I biosynthetic process |
| positive regulation of type I interferon-mediated signaling pathway |
| negative regulation of type I interferon-mediated signaling pathway |
| regulation of interferon-gamma-mediated signaling pathway |
| regulation of response to interferon-gamma |
| regulation of type I interferon-mediated signaling pathway |
| negative regulation of type I interferon production |
| positive regulation of cytokine-mediated signaling pathway |
| negative regulation of innate immune response |
| positive regulation of response to cytokine stimulus |
| negative regulation of cytokine-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| negative regulation of NF-kappaB transcription factor activity |
| negative regulation of response to biotic stimulus |
| regulation of type I interferon production |
| negative regulation of immune response |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| defense response to virus |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| negative regulation of cytokine production |
| response to virus |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| regulation of innate immune response |
| positive regulation of defense response |
| centrosome |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| response to bacterium |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| positive regulation of immune response |
| regulation of kinase activity |
| defense response to other organism |
| regulation of transferase activity |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3261
- Expression level (log2 read counts): 6.27
Expression Distribution
NLRC5 Expression in NALM6 Cells: 6.27
