NLRP5
Gene Information
- Official Symbol: NLRP5
- Official Name: NLR family pyrin domain containing 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 126206
- UniProt: P59047
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7745
- Expression level (log2 read counts): -3.51
NLRP5 Expression in NALM6 Cells: -3.51
