NOG
Gene Information
- Official Symbol: NOG
- Official Name: noggin
- Aliases and Previous Symbols: N/A
- Entrez ID: 9241
- UniProt: Q13253
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008].
- UniProt Summary: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273, ECO:0000269|PubMed:26643732}.
Pfam Domains GO Terms
Pfam Domains
| Noggin |
GO Terms
| fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation |
| regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation |
| negative regulation of cardiac epithelial to mesenchymal transition |
| negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| negative regulation of cytokine activity |
| ureteric bud formation |
| neural plate anterior/posterior regionalization |
| prostatic bud formation |
| regulation of cytokine activity |
| neural plate regionalization |
| BMP signaling pathway involved in heart development |
| atrial cardiac muscle tissue morphogenesis |
| neural plate pattern specification |
| mesonephric tubule formation |
| neural plate morphogenesis |
| morphogenesis of an epithelial bud |
| atrial cardiac muscle tissue development |
| axial mesoderm development |
| pharyngeal arch artery morphogenesis |
| ventricular compact myocardium morphogenesis |
| regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| lateral sprouting from an epithelium |
| membranous septum morphogenesis |
| neural plate development |
| notochord morphogenesis |
| embryonic skeletal joint morphogenesis |
| positive regulation of glomerulus development |
| regulation of cardiac epithelial to mesenchymal transition |
| negative regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of receptor binding |
| negative regulation of astrocyte differentiation |
| negative regulation of cardiac muscle cell proliferation |
| regulation of transcription from RNA polymerase II promoter involved in heart development |
| embryonic skeletal joint development |
| regulation of glomerulus development |
| nephron tubule formation |
| morphogenesis of an epithelial fold |
| positive regulation of branching involved in ureteric bud morphogenesis |
| cell differentiation in hindbrain |
| notochord development |
| middle ear morphogenesis |
| positive regulation of mesonephros development |
| prostate gland epithelium morphogenesis |
| regulation of branching involved in ureteric bud morphogenesis |
| negative regulation of cardiac muscle tissue growth |
| negative regulation of heart growth |
| prostate gland morphogenesis |
| regulation of receptor binding |
| cell surface receptor signaling pathway involved in heart development |
| regulation of mesonephros development |
| negative regulation of glial cell differentiation |
| pharyngeal system development |
| regulation of astrocyte differentiation |
| negative regulation of epithelial to mesenchymal transition |
| motor neuron axon guidance |
| negative regulation of cartilage development |
| regulation of fibroblast growth factor receptor signaling pathway |
| cardiac atrium morphogenesis |
| negative regulation of organ growth |
| negative regulation of cardiac muscle tissue development |
| heart trabecula morphogenesis |
| face morphogenesis |
| positive regulation of morphogenesis of an epithelium |
| animal organ formation |
| negative regulation of animal organ morphogenesis |
| endocardial cushion morphogenesis |
| cardiac atrium development |
| head morphogenesis |
| cytokine binding |
| regulation of heart morphogenesis |
| regulation of cardiac muscle cell proliferation |
| positive regulation of kidney development |
| negative regulation of gliogenesis |
| ventricular septum morphogenesis |
| prostate gland development |
| pituitary gland development |
| lung morphogenesis |
| negative regulation of osteoblast differentiation |
| endocardial cushion development |
| trabecula morphogenesis |
| body morphogenesis |
| endoderm formation |
| negative regulation of striated muscle tissue development |
| ventricular cardiac muscle tissue morphogenesis |
| face development |
| negative regulation of muscle organ development |
| negative regulation of BMP signaling pathway |
| mesenchyme morphogenesis |
| negative regulation of muscle tissue development |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| ventricular cardiac muscle tissue development |
| regulation of morphogenesis of a branching structure |
| regulation of cardiac muscle tissue growth |
| regulation of pathway-restricted SMAD protein phosphorylation |
| embryonic digit morphogenesis |
| artery morphogenesis |
| regulation of heart growth |
| nephron tubule morphogenesis |
| somatic stem cell population maintenance |
| nephron epithelium morphogenesis |
| mesoderm formation |
| nephron morphogenesis |
| cardiac muscle tissue morphogenesis |
| renal tubule morphogenesis |
| mesoderm morphogenesis |
| regulation of glial cell differentiation |
| epithelial to mesenchymal transition |
| regulation of cartilage development |
| ventricular septum development |
| endoderm development |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| negative regulation of ossification |
| cardiac ventricle morphogenesis |
| diencephalon development |
| nephron tubule development |
| regulation of cardiac muscle tissue development |
| renal tubule development |
| fibroblast growth factor receptor signaling pathway |
| muscle tissue morphogenesis |
| positive regulation of animal organ morphogenesis |
| dorsal/ventral pattern formation |
| somite development |
| regulation of epithelial to mesenchymal transition |
| kidney morphogenesis |
| artery development |
| ureteric bud development |
| muscle organ morphogenesis |
| mesonephric epithelium development |
| mesonephric tubule development |
| regulation of BMP signaling pathway |
| BMP signaling pathway |
| mesonephros development |
| neural tube closure |
| tube closure |
| embryonic skeletal system morphogenesis |
| regulation of organ growth |
| nephron epithelium development |
| primary neural tube formation |
| gland morphogenesis |
| negative regulation of protein binding |
| negative regulation of developmental growth |
| response to BMP |
| cellular response to BMP stimulus |
| neural tube formation |
| spinal cord development |
| cellular response to fibroblast growth factor stimulus |
| cardiac septum development |
| formation of primary germ layer |
| regulation of osteoblast differentiation |
| regulation of gliogenesis |
| response to fibroblast growth factor |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| ear morphogenesis |
| endocrine system development |
| embryonic epithelial tube formation |
| mesoderm development |
| nephron development |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| osteoblast differentiation |
| cardiac chamber morphogenesis |
| embryonic skeletal system development |
| cardiac ventricle development |
| kidney epithelium development |
| epithelial tube formation |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| stem cell population maintenance |
| regulation of muscle organ development |
| maintenance of cell number |
| morphogenesis of embryonic epithelium |
| negative regulation of cellular response to growth factor stimulus |
| tube formation |
| limb morphogenesis |
| appendage morphogenesis |
| hindbrain development |
| mesenchymal cell differentiation |
| morphogenesis of a branching epithelium |
| gastrulation |
| neural tube development |
| cardiac muscle tissue development |
| morphogenesis of a branching structure |
| lung development |
| negative regulation of binding |
| cardiac chamber development |
| cartilage development |
| respiratory tube development |
| regulation of signaling receptor activity |
| negative regulation of canonical Wnt signaling pathway |
| limb development |
| appendage development |
| regulation of morphogenesis of an epithelium |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| respiratory system development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of Wnt signaling pathway |
| anterior/posterior pattern specification |
| regulation of protein binding |
| mesenchyme development |
| ear development |
| connective tissue development |
| negative regulation of apoptotic signaling pathway |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| negative regulation of growth |
| heart morphogenesis |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| negative regulation of cell migration |
| axon guidance |
| neuron projection guidance |
| ossification |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cell motility |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| renal system development |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| urogenital system development |
| negative regulation of locomotion |
| regulation of developmental growth |
| regionalization |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| regulation of Wnt signaling pathway |
| axonogenesis |
| regulation of binding |
| in utero embryonic development |
| forebrain development |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| axon development |
| gland development |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of phosphorylation |
| muscle structure development |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| skeletal system development |
| cellular response to growth factor stimulus |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| cardiovascular system development |
| heart development |
| response to growth factor |
| sensory organ development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| neuron differentiation |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12452
- Expression level (log2 read counts): -1.98
Expression Distribution
NOG Expression in NALM6 Cells: -1.98
