NPNT
Gene Information
- Official Symbol: NPNT
- Official Name: nephronectin
- Aliases and Previous Symbols: N/A
- Entrez ID: 255743
- UniProt: Q6UXI9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| EGF CA |
| EGF 3 |
| MAM |
| cEGF |
GO Terms
| positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation |
| pilomotor reflex |
| integrin alpha8-beta1 complex |
| smooth muscle contractile fiber |
| cell-cell adhesion mediated by integrin |
| positive regulation of alkaline phosphatase activity |
| regulation of alkaline phosphatase activity |
| reflex |
| cell adhesion mediated by integrin |
| positive regulation of cellular response to transforming growth factor beta stimulus |
| positive regulation of transforming growth factor beta receptor signaling pathway |
| positive regulation of smooth muscle contraction |
| smooth muscle cell differentiation |
| positive regulation of phosphatase activity |
| branching involved in ureteric bud morphogenesis |
| positive regulation of muscle contraction |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| positive regulation of dephosphorylation |
| positive regulation of osteoblast differentiation |
| regulation of smooth muscle contraction |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| nephron tubule development |
| renal tubule development |
| kidney morphogenesis |
| positive regulation of ossification |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| basement membrane |
| mesonephros development |
| nephron epithelium development |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of osteoblast differentiation |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| positive regulation of cell-substrate adhesion |
| nephron development |
| cell-matrix adhesion |
| kidney epithelium development |
| integrin binding |
| branching morphogenesis of an epithelial tube |
| extracellular matrix structural constituent |
| morphogenesis of a branching epithelium |
| regulation of muscle contraction |
| morphogenesis of a branching structure |
| regulation of phosphatase activity |
| cell-substrate adhesion |
| regulation of ossification |
| regulation of cell-substrate adhesion |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of dephosphorylation |
| regulation of muscle system process |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to tumor necrosis factor |
| muscle cell differentiation |
| response to tumor necrosis factor |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| renal system development |
| regulation of ERK1 and ERK2 cascade |
| epithelial tube morphogenesis |
| urogenital system development |
| extracellular matrix organization |
| collagen-containing extracellular matrix |
| extracellular structure organization |
| positive regulation of cell adhesion |
| morphogenesis of an epithelium |
| muscle structure development |
| cell-cell adhesion |
| positive regulation of MAPK cascade |
| tissue morphogenesis |
| regulation of system process |
| tube morphogenesis |
| regulation of cell adhesion |
| calcium ion binding |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| tube development |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| response to cytokine |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8494
- Expression level (log2 read counts): -2.84
Expression Distribution
NPNT Expression in NALM6 Cells: -2.84
