NPY5R
Gene Information
- Official Symbol: NPY5R
- Official Name: neuropeptide Y receptor Y5
- Aliases and Previous Symbols: N/A
- Entrez ID: 4889
- UniProt: Q15761
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| generation of ovulation cycle rhythm |
| peptide YY receptor activity |
| pancreatic polypeptide receptor activity |
| negative regulation of glutamate secretion |
| negative regulation of acute inflammatory response to antigenic stimulus |
| negative regulation of synaptic transmission, GABAergic |
| neuropeptide Y receptor activity |
| negative regulation of amino acid transport |
| negative regulation of inflammatory response to antigenic stimulus |
| negative regulation of acute inflammatory response |
| regulation of acute inflammatory response to antigenic stimulus |
| cardiac left ventricle morphogenesis |
| regulation of glutamate secretion |
| negative regulation of organic acid transport |
| regulation of inflammatory response to antigenic stimulus |
| negative regulation of amine transport |
| negative regulation of anion transport |
| positive regulation of acute inflammatory response |
| eating behavior |
| regulation of amino acid transport |
| regulation of synaptic transmission, GABAergic |
| ovulation cycle process |
| regulation of acute inflammatory response |
| regulation of organic acid transport |
| negative regulation of synaptic transmission |
| ovulation cycle |
| outflow tract morphogenesis |
| cardiac ventricle morphogenesis |
| feeding behavior |
| positive regulation of smooth muscle cell proliferation |
| regulation of amine transport |
| regulation of anion transport |
| neuropeptide signaling pathway |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of smooth muscle cell proliferation |
| negative regulation of inflammatory response |
| positive regulation of inflammatory response |
| negative regulation of ion transport |
| negative regulation of immune response |
| cardiac chamber development |
| negative regulation of secretion by cell |
| negative regulation of defense response |
| positive regulation of ERK1 and ERK2 cascade |
| negative regulation of secretion |
| heart morphogenesis |
| rhythmic process |
| aging |
| regulation of ERK1 and ERK2 cascade |
| neuron projection |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| positive regulation of defense response |
| negative regulation of transport |
| heart development |
| positive regulation of MAPK cascade |
| behavior |
| positive regulation of response to external stimulus |
| regulation of ion transport |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| circulatory system development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cadmium 60μM R08 exp462 | 1.85 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.405 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12805
- Expression level (log2 read counts): -6.6
Expression Distribution
NPY5R Expression in NALM6 Cells: -6.6
