NTS
Gene Information
- Official Symbol: NTS
- Official Name: neurotensin
- Aliases and Previous Symbols: N/A
- Entrez ID: 4922
- UniProt: P30990
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014].
- UniProt Summary: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17365
- Expression level (log2 read counts): -7.68
NTS Expression in NALM6 Cells: -7.68
