OLFM2
Gene Information
- Official Symbol: OLFM2
- Official Name: olfactomedin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 93145
- UniProt: O95897
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). {ECO:0000250|UniProtKB:Q568Y7, ECO:0000250|UniProtKB:Q8BM13, ECO:0000269|PubMed:25298399}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5452
- Expression level (log2 read counts): -2.69
OLFM2 Expression in NALM6 Cells: -2.69
